North Texas Traumatic Brain Injury Model System

This proposal requests continuation of the North Texas Traumatic Brain Injury Model System (NT-TBIMS) center which has been continuously funded by NIDRR for the last ten years. Purpose: The purpose of this proposal is to improve the outcomes of TBI patients in North Texas region and beyond by providing multidisciplinary state-of-the-art care to meet the needs of TBI patients and families, through expertise in Trauma, Neurosurgery, Neurology, Neuropsychology, Neuroradiology, and all disciplines of Physical Medicine and Rehabilitation.

Target population: North Texas region comprises the Dallas-Fort Worth metropolitan area, the fourth largest in the country. NT-TBIMS serves a large and diverse population (over 6.5 million people, 38% minorities), including the underserved. It is a public-private partnership of the three largest hospital systems in North Texas: Baylor Health Care System (private not-for-profit), University of Texas Southwestern (UTSW)/Parkland Hospital and Health System (public), and JPS Health Network (public). This collaboration enables us to serve patients with TBI treated at all three Level I trauma centers in the region and two major inpatient rehab facilities.

Goals and Objectives:
1. To enroll seventy patients each year in TBIMS.

2. To collaborate on module projects. During the current funding cycle, NT-TBIMS has contributed patients for three module projects, beyond the one project required by NIDRR.

3. To develop novel interventions in TBI rehab by conducting two local research projects:

Project 1: Comparative effectiveness study of variations in clinical practices and patient outcomes across TBIMS rehab centers and to develop evidence-based practice guidelines for TBI rehab.

Project 2: To identify TBI patients that may benefit from early methylphenidate therapy utilizing Single Photon Emission Computed Tomography (SPECT) imaging of dopamine transporter.

4. To disseminate TBIMS research findings in North Texas region by conducting seminars, presenting at professional and consumer meetings, and publishing in professional and consumer journals, in collaboration with TBIMS Knowledge Translation Center.

Methodological Approach: NT-TBIMS will maintain its infrastructure that has enabled it to successfully enroll patients for the last ten years. Proposed enhancements include addition of JPS Health Network, participation of investigators for comparative effectiveness research and state of-the-art neuroimaging to identify TBI patients that may benefit from methylphenidate therapy.

Anticipated Project Outcomes: NT-TBIMS expects to continue as a leading center in enrolling patients in TBIMS, assist other TBIMS centers in their research endeavor through participation in module projects, and complete two local research projects that will generate evidence-based guidelines in TBI rehab practices and enable clinicians to identify TBI patients that may benefit from early Methylphenidate therapy.

Baylor Research Institute @ Baylor Institute for Rehabilitation

909 N Washington
Dallas TX 75426

Project Officer: Cate Miller, Ph.D.
Project Number: H133A120098
Shahid Shafi, M.D., M.P.H.
Project Director - BIR/ 820-9593
Kyle Womack, M.D.
Project Director - UTSW Dept of 648-7613
Kathleen Bell, MD
P&M Department Chair - 648-9377
Randi Dubiel, D.O.
TBI Medical Director - 820-9593
John Thottakara, M.D.
TBI Medical Director - 648-3315
Marie Dahdah, Ph.D.
Clinical Psychologist - 814-4816
Simon Driver, Ph.D.
Director of Research - 820-9014
Cindy Dunklin, B.S., CCRC
Project Coordinator - 820-9640
Caryn R. Harper, M.S., CCRC
Project Coordinator - 648-7613
Libby Callender, B.S., CCRC
Clinical Research Coordinator - 820-9988
Shannon Juengst, PhD
Assistant Professor - 648-5352
Sunni Barnes, Ph.D.
Biostatistician - 265-3634
Ezequiel Cambranis
Clinical Research Coordinator - 648-2926
Amber Merfeld
Clinical Research 210-0764
Monica Watford, PhD
Clinical Research 820-9356