The University of Pittsburgh Model Center Traumatic Brain Injury Program (UPMC-TBI) reflects a greater than $15 million institutional commitment, extraordinary facilities and a dedication to patient care and research. UPMC-TBI’s continuum of care spans the time from the emergency response scene through community reintegration. The rich research resources available with UPMC-TBI allow us to participate in any multisite research modules selected by the NIDRR TBI Model Systems network. Our work developing the fundamental concept of Rehabilomics research supports our research leadership and productivity in the area of dopamine system dysfunction following TBI. Our preliminary data suggests that genetic variation in dopamine related genes plays an important role in TBI recovery, and we propose to explore these relationships further using an robust Rehabilomics framework that incorporates the World Health Organization’s International Classification of Functioning Disability and Health (ICF). We include a rehabilitation technology pilot component for developing ecological momentary assessment tools for real-time symptom journaling and data collection tailored to individuals with TBI, infrastructure that will critically link biomarkers and other molecular signatures with ICF grounded assessments. Our accomplishments in TBI biomarkers in rehabilitation research have been seminal, and we are committed to advancing NIDRR priorities though the application of Rehabilomics principles that lead to the development of systems-based and best practice approaches to person centered care and that maximally impact function and recovery. Knowledge from our high impact research will, in the short, medium and long term, translate to neurobiologically grounded & personalized care. Dissemination to our local & national professional & consumer communities will be enhanced through the Model Systems Knowledge Translation Center. We are pleased to present this application for a NIDRR TBI Model System.