This proposal requests continuation of the North Texas Traumatic Brain Injury Model System (NT-TBIMS) center which has been continuously funded by NIDRR for the last ten years. Purpose: The purpose of this proposal is to improve the outcomes of TBI patients in North Texas region and beyond by providing multidisciplinary state-of-the-art care to meet the needs of TBI patients and families, through expertise in Trauma, Neurosurgery, Neurology, Neuropsychology, Neuroradiology, and all disciplines of Physical Medicine and Rehabilitation.
Target population: North Texas region comprises the Dallas-Fort Worth metropolitan area, the fourth largest in the country. NT-TBIMS serves a large and diverse population (over 6.5 million people, 38% minorities), including the underserved. It is a public-private partnership of the three largest hospital systems in North Texas: Baylor Health Care System (private not-for-profit), University of Texas Southwestern (UTSW)/Parkland Hospital and Health System (public), and JPS Health Network (public). This collaboration enables us to serve patients with TBI treated at all three Level I trauma centers in the region and two major inpatient rehab facilities.
Goals and Objectives:
1. To enroll seventy patients each year in TBIMS.
2. To collaborate on module projects. During the current funding cycle, NT-TBIMS has contributed patients for three module projects, beyond the one project required by NIDRR.
3. To develop novel interventions in TBI rehab by conducting two local research projects:
Project 1: Comparative effectiveness study of variations in clinical practices and patient outcomes across TBIMS rehab centers and to develop evidence-based practice guidelines for TBI rehab.
Project 2: To identify TBI patients that may benefit from early methylphenidate therapy utilizing Single Photon Emission Computed Tomography (SPECT) imaging of dopamine transporter.
4. To disseminate TBIMS research findings in North Texas region by conducting seminars, presenting at professional and consumer meetings, and publishing in professional and consumer journals, in collaboration with TBIMS Knowledge Translation Center.
Methodological Approach: NT-TBIMS will maintain its infrastructure that has enabled it to successfully enroll patients for the last ten years. Proposed enhancements include addition of JPS Health Network, participation of investigators for comparative effectiveness research and state of-the-art neuroimaging to identify TBI patients that may benefit from methylphenidate therapy.
Anticipated Project Outcomes: NT-TBIMS expects to continue as a leading center in enrolling patients in TBIMS, assist other TBIMS centers in their research endeavor through participation in module projects, and complete two local research projects that will generate evidence-based guidelines in TBI rehab practices and enable clinicians to identify TBI patients that may benefit from early Methylphenidate therapy.