The Southeastern Michigan Traumatic Brain Injury System (SEMTBIS) at Wayne State University and the Detroit Medical Center has been with the Model Systems project since 1987. The SEMTBIS has two main research projects and will contribute to two TBIMS module projects. Additionally, the SEMTBIS continues to participate in longitudinal data collection that is submitted quarterly to the TBIMS national database.
Research Projects
Utility of MRI Techniques in Prediction of TBI Outcome
This project aims to develop multivariable imaging models using three innovative techniques (i.e., Diffusion Tensor Imaging, Susceptibility Weighted Imaging, and Magnetic Resonance Spectroscopy), to improve the prediction of neurobehavioral and functional outcomes at two key time points – discharge from inpatient hospitalization and one year post injury. It will also examine the depth of lesion model, which posits that the deeper the lesion the greater the disability.
Safety and Feasibility of Minocycline in the Treatment of TBI
This is a Phase IIa study designed to establish optimal dosage of minocycline given acutely following TBI. The study will gather preliminary functional outcome data in an attempt to conduct a clinical feasibility assessment with this drug.
Collaborative Modules
Environmental Influences Affecting Outcomes from TBI - Geographical Identifiers (GeoID)
This module aims to enhance core dataset to expand research on environmental influences affecting outcomes from TBI. This module will evaluate the feasibility, reliability, and utility of recording geographic identifiers for place of residence after TBI.
Sexuality after TBI
This collaborate project examines the frequency, type, and severity of changes in sexual function associated with TBI.